Muhilal, Murdiana, A., Azis, I., Saidin, S., Jahari, A. B., and Karyadi, D. Vitamin A-fortified monosodium glutamate and vitamin A status: a controlled field trial. Am.J Clin.Nutr 1988;48(5):1265-1270. View abstract. Heinz, J., Kropf, S., Luley, C., and Dierkes, J. Homocysteine as a risk factor for cardiovascular disease in patients treated by dialysis: a meta-analysis. Am J Kidney Dis. 2009;54(3):478-489. View abstract. de, Bree A., Mennen, L. I., Hercberg, S., and Galan, P. Evidence for a protective (synergistic?) effect of B-vitamins and omega-3 fatty acids on cardiovascular diseases. Eur.J Clin.Nutr 2004;58(5):732-744. View abstract.

Butler, C. C., Vidal-Alaball, J., Cannings-John, R., McCaddon, A., Hood, K., Papaioannou, A., Mcdowell, I., and Goringe, A. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials. Fam.Pract 2006;23(3):279-285. View abstract. Callaghan TS, Hadden DR, Tomkin GH. Megaloblastic anemia due to vitamin B12 malabsorption associated with longterm metformin treatment. Br Med J 1980;280:1214-5. View abstract. Thu, B. D., Schultink, W., Dillon, D., Gross, R., Leswara, N. D., and Khoi, H. H. Effect of daily and weekly micronutrient supplementation on micronutrient deficiencies and growth in young Vietnamese children. Am J Clin Nutr 1999;69(1):80-86. View abstract.Malouf, R. and Areosa, Sastre A. Vitamin B12 for cognition. Cochrane.Database.Syst.Rev. 2003;(3):CD004326. View abstract. Ellinson, M., Thomas, J., and Patterson, A. A critical evaluation of the relationship between serum vitamin B, folate and total homocysteine with cognitive impairment in the elderly. J Hum Nutr Diet 2004;17(4):371-383. View abstract. Kwasniewska, A., Tukendorf, A., and Semczuk, M. Folate deficiency and cervical intraepithelial neoplasia. Eur J Gynaecol.Oncol 1997;18(6):526-530. View abstract. Hunt, J. R., Mullen, L. M., Lykken, G. I., Gallagher, S. K., and Nielsen, F. H. Ascorbic acid: effect on ongoing iron absorption and status in iron-depleted young women. Am.J Clin.Nutr 1990;51(4):649-655. View abstract. Roderique, E. J., Gebre-Giorgis, A. A., Stewart, D. H., Feldman, M. J., and Pozez, A. L. Smoke inhalation injury in a pregnant patient: a literature review of the evidence and current best practices in the setting of a classic case. J Burn Care Res 2012;33(5):624-633. View abstract.

Simeonov, S., Pavlova, M., Mitkov, M., Mincheva, L., and Troev, D. Therapeutic efficacy of "Milgamma" in patients with painful diabetic neuropathy. Folia Med (Plovdiv.) 1997;39(4):5-10. View abstract. Chawla, P. K. and Puri, R. Impact of nutritional supplements on hematological profile of pregnant women. Indian Pediatr. 1995;32(8):876-880. View abstract. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. View abstract.

Fact Box

Liu, D. S., Bates, C. J., Yin, T. A., Wang, X. B., and Lu, C. Q. Nutritional efficacy of a fortified weaning rusk in a rural area near Beijing. Am J Clin Nutr 1993;57(4):506-511. View abstract. Basu, R. N., Sood, S. K., Ramachandran, K., Mathur, M., and Ramalingaswami, V. Etiopathogenesis of nutritional anemia in pregnancy: a therapeutic approach. Am.J Clin.Nutr 1973;26(6):591-594. View abstract. Weir, D. G. and Scott, J. M. Homocysteine as a risk factor for cardiovascular and related disease: nutritional implications. Nutr Res.Rev 1998;11(2):311-338. View abstract. Dong H, Pi F, Ding Z, Chen W, Pang S, Dong W, Zhang Q. Efficacy of supplementation with B Vitamins for stroke prevention: A network meta-analysis of randomized controlled trials. PLoS One. 2015;10(9):e0137533. View abstract. Alzheimer disease. Taking vitamin B12 by mouth, alone or with folic acid and vitamin B6, doesn't seem to improve mental function in people with Alzheimer disease.

Naurath, H. J., Joosten, E., Riezler, R., Stabler, S. P., Allen, R. H., and Lindenbaum, J. Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations. Lancet 7-8-1995;346(8967):85-89. View abstract. Giuliano, A. R., Papenfuss, M., Nour, M., Canfield, L. M., Schneider, A., and Hatch, K. Antioxidant nutrients: associations with persistent human papillomavirus infection. Cancer Epidemiol.Biomarkers Prev. 1997;6(11):917-923. View abstract. Ford, A. H. and Almeida, O. P. Effect of homocysteine lowering treatment on cognitive function: a systematic review and meta-analysis of randomized controlled trials. J.Alzheimers.Dis. 2012;29(1):133-149. View abstract.

Appointments at Mayo Clinic

Woodside, J. V., Young, I. S., Yarnell, J. W., McMaster, D., and Evans, A. E. The effects of oral vitamin supplementation on cardiovascular risk factors. Proc Nutr Soc 1997;56(1B):479-488. View abstract. Suboticanec, K., Stavljenic, A., Schalch, W., and Buzina, R. Effects of pyridoxine and riboflavin supplementation on physical fitness in young adolescents. Int J Vitam.Nutr Res. 1990;60(1):81-88. View abstract. Deutch B, Jorgensen EB, Hansen JC. n-3 PUFA from fish or seal oil reduce atherogenic risk indicators in Danish women. Nutr Res 2000;20:1065-77. Van, Dam F. and Van Gool, W. A. Hyperhomocysteinemia and Alzheimer's disease: A systematic review. Arch.Gerontol.Geriatr. 2009;48(3):425-430. View abstract.

Vermeulen, E. G., Rauwerda, J. A., Erix, P., de Jong, S. C., Twisk, J. W., Jakobs, C., Witjes, R. J., and Stehouwer, C. D. Normohomocysteinaemia and vitamin-treated hyperhomocysteinaemia are associated with similar risks of cardiovascular events in patients with premature atherothrombotic cerebrovascular disease. A prospective cohort study. Neth.J Med 2000;56(4):138-146. View abstract. Franken, D. G., Boers, G. H., Blom, H. J., and Trijbels, J. M. Effect of various regimens of vitamin B6 and folic acid on mild hyperhomocysteinaemia in vascular patients. J Inherit.Metab Dis. 1994;17(1):159-162. View abstract. Badner NH, Freeman D, Spence JD. Preoperative oral B vitamins prevent nitrous oxide-induced postoperative plasma homocysteine increases. Anesth Analg 2001;93:1507-10.. View abstract.Bottiglieri T, Laundy M, Crellin R, et al. Homocysteine, folate, methylation, and monoamine metabolism in depression. J Neurol Neurosurg Psychiatry 2000;69:228-32.. View abstract. Didangelos T, Karlafti E, Kotzakioulafi E, et al. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021;13(2):395. View abstract.